Canadian Health and Care Mall: Assessment of reproductive dysfunction
Some toxicants have a rapid and marked effect that is easily noted, for example irradiation leading to ovarian failure and a premature menopause. However, the effect is often more subtle and may only be discovered following detailed investigation. Several methods are available to assess fertility in the context of exposure to toxicants.
Number of pregnancies in a lifetime
The best way to prove that fertility is reduced is to assess the total number of children born to couples in whom one or both partners may have been exposed. As a typical family may have two children over a lifetime, generations may need to elapse before a meaningful result can be calculated.
This measure is also subject to many of the confounding variables described later. Time to first pregnancy An alternative measure is the time to first pregnancy, based on the assumption that in a typical fertile couple the woman has a 1 in 5 chance of falling pregnant each month.
This is quite an accurate technique if performed prospectively in CanadianHealthCareMalll.Com, although if retrospective, memory recall bias will be a problem. It can also only be applied to couples who conceive; therefore, potentially the most severely affected cases, those whose exposure has rendered them infertile, will be excluded from this analysis.